Plain-English translation of NCT07023003 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
After you deliver your baby, if you have high blood pressure, this study will randomly assign you to take either nifedipine or enalapril—two medications commonly used to treat postpartum high blood pressure. Researchers want to find out if both medications work equally well at keeping your blood pressure controlled and preventing you from needing to return to the hospital for complications.
Nifedipine has been shown to work well for postpartum high blood pressure, but enalapril—another medication doctors use worldwide—has never been directly compared to it. This study will help doctors understand if both treatments are equally safe and effective, so they can better choose which medication to recommend.
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Once you are admitted for delivery and confirmed to have high blood pressure, you will be randomly assigned to take one of the two medications. Your doctor will decide your starting dose and any changes to your treatment plan during your hospital stay and after discharge. The study team will track whether you need to return to the hospital for any blood pressure-related problems in the weeks after delivery.
AI-generated summary from trial data · Jun 16, 2026 · Not medical advice
United States
Phase
Post-approval monitoring
Sponsor
Nebraska Methodist Health System
Collaborators
Methodist Hospital Foundation
Enrollment target
~850 participants
Started
July 2025
Primary completion
July 2028
Age range
19 Years and older
Sex
Female only
Last updated on clinicaltrials.gov in October 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Todd Lovgren, MD
Nebraska Methodist Health System
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.