Plain-English translation of NCT07023523 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study explores how your brain can learn to better manage fibromyalgia pain using a technique called real-time brain imaging feedback. Researchers will show you live images of your brain activity while you're inside an MRI scanner, helping you practice strategies to reduce negative thoughts about pain. You'll then participate in either cognitive behavioral therapy (a talk-based treatment focused on changing pain-related thoughts) or fibromyalgia education sessions over 8 weeks to see which approach helps most.
Many people with fibromyalgia get stuck in a pattern of catastrophizing—dwelling on pain and expecting the worst—which can make pain feel worse. Researchers want to understand how the brain controls this pattern and whether directly training your brain to self-regulate, combined with therapy, could break this cycle and improve outcomes.
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You will have an initial MRI visit where you'll complete questionnaires, discuss pain-management strategies with the research team, and then enter an MRI scanner to practice brain-imaging feedback while mild pressure is applied to your leg to trigger pain responses. After that baseline visit, you'll be randomly assigned to either 8 weekly cognitive behavioral therapy sessions or 8 weekly fibromyalgia education sessions with a psychologist. Finally, you'll return for a follow-up MRI visit identical to the first one to see how your brain's responses have changed.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
United States