Plain-English translation of NCT07023666 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Sickle Cell Disease research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is designed to help people with sickle cell disease catch heart problems caused by iron buildup before they become serious. You'll receive iron chelation therapy (medication that removes excess iron from your body) along with standard heart medicines, while your heart is checked regularly with imaging tests and blood work over one year.
People with sickle cell disease often receive many blood transfusions, which can cause dangerous iron buildup in the heart. This trial exists to find out whether catching and treating iron overload early—before symptoms appear—can prevent lasting heart damage.
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You will visit the clinic every 3 months for one year. At each visit, you'll have heart tests (an ECG, ultrasound of your heart, and possibly an MRI), blood work to check your iron levels, and you'll receive iron chelation medication along with other heart medicines as prescribed. The whole commitment is 12 months of regular monitoring and treatment aimed at protecting your heart.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
United States