Plain-English translation of NCT07025590 on ClinicalTrials.gov โ ยท Source last updated ยท Translation generated ยท How we translate trials
This study doesn't follow the usual testing phases โ it may be an observational study or a different type of research.
This study looks at whether moderate-intensity exercise, combined with antidepressant medications like sertraline, escitalopram, or fluoxetine, can help people with both heart disease and depression or anxiety symptoms. The goal is to see if exercise allows patients to gradually take lower doses of their medication while maintaining symptom relief. This is important because antidepressants work well but can have side effects, and exercise offers a complementary treatment with its own mental and physical health benefits.
Many people with heart disease also struggle with depression or anxiety, which can worsen their heart condition. While antidepressant medications help quickly, they don't work perfectly for everyone and can cause side effects. Recent research shows that exercise is a safe, effective way to reduce depression and anxiety symptoms. This trial wants to find out whether combining exercise with the medication allows patients to safely reduce their doses over time.
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If you join this study, you will be assigned to either an exercise-plus-medication group or a medication-only group. The exercise group will participate in moderate-intensity continuous exercise training while taking their antidepressant medication, with the goal of gradually reducing the medication dose over time. You'll attend regular visits to monitor your heart health, mood symptoms, and medication levels. The study involves multiple medical centers and will track your progress to see whether exercise helps you need less medication while staying well.
AI-generated summary from trial data ยท Jun 14, 2026 ยท Not medical advice
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