Testing two timing patterns of brain stimulation for depression

This trial is testing theta-burst stimulation (TBS), a non-invasive brain stimulation technique that uses magnetic pulses to help restore healthy brain function in people with depression. Researchers are comparing two different timing patterns—one with treatments spread out over time, and one delivered more densely—to see which approach works better at reducing depression symptoms.

While antidepressant medications help many people, they don't work well enough for everyone and often cause side effects like weight gain, drowsiness, and sexual dysfunction. This treatment aims to improve brain plasticity (the brain's ability to form new connections) in a way that current treatments cannot, potentially offering a more effective option for people whose depression hasn't improved enough with medication alone.