Testing a new immune cell therapy for Sjögren's disease

This trial is testing CLN-978, a new treatment given as injections under the skin. The medication works by enlisting your immune system to target and reduce certain B cells that may be driving your Sjögren's disease. Researchers want to find the right dose and learn whether this approach can safely improve symptoms like dry eyes and dry mouth.

Sjögren's disease is an autoimmune condition where your immune system attacks the glands that make tears and saliva, leaving people with very dry, uncomfortable eyes and mouth. Current treatments don't work well enough for many patients, so this trial is exploring a novel approach that uses your own immune system in a new way to fight the disease.