Simplified radiation treatment for small liver tumors

Plain-English translation of NCT07043387 on ClinicalTrials.gov ↗ · Source last updated July 2025 · Translation generated June 2026 · How we translate trials

What is this trial?

This trial is studying a procedure called radioembolization, which delivers tiny radioactive beads directly into liver tumors to destroy them. The study is testing whether doctors can skip one of the standard pre-treatment safety scans (called a MAA scan) for patients with smaller tumors, based on 10 years of hospital experience showing these patients almost never have complications from the radiation reaching their lungs.

The standard treatment process currently requires two scans before radioembolization: an angiography and a nuclear medicine scan to check if radiation might reach the lungs. This research aims to simplify and speed up the process for patients with smaller, lower-risk tumors, while keeping them just as safe.

Do you qualify?

You likely qualify if…

you are 19 years or older
you have been diagnosed with colorectal cancer, cholangiocarcinoma, or other metastatic liver cancer that has spread to your liver
your largest tumor is 7 centimeters or smaller, and you have 5 or fewer tumors
you have healthy blood counts, liver function, and kidney function (recent blood work shows values within safe ranges)
you have a life expectancy of at least 3 months and are in good enough health to undergo the procedure

You likely don't qualify if…

you have cancer that has invaded your hepatic veins or portal veins
you have abnormal blood vessel patterns within your tumors (dysmorphic vessels larger than 3 millimeters)
you have a biliary stent or surgically created bile duct connection
you have severe lung disease or emphysema that could be worsened by radiation
you have a severe allergy to contrast dye or cannot safely undergo angiography

What participation looks like

If you join this trial, you would receive radioembolization without the standard pre-treatment MAA scan—the doctors will rely on your imaging scans and medical history to determine safety instead. You'll still have an angiography (a procedure where a thin tube is placed into blood vessels to map the tumor's blood supply), and the radioactive treatment itself. The study collects information about your health, treatment results, and any side effects over time as part of a registry.

Simplified radiation treatment for small liver tumors

What is this trial?

Do you qualify?

What participation looks like

Trial locations(4 sites)