Plain-English translation of NCT07045142 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Schizophrenia research guide →Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
People with schizophrenia who take antipsychotic medications often develop high cholesterol and need to take a cholesterol-lowering drug called . However, can sometimes raise blood sugar levels and increase diabetes risk. This study tests whether adding —a common medication used to prevent or treat diabetes—can help protect your blood sugar while you're taking the cholesterol medication.
People with schizophrenia are at much higher risk for heart disease and early death compared to the general population. While the cholesterol medication helps protect the heart, it may harm blood sugar control in this group—a side effect that hasn't been well studied in schizophrenia patients. This trial aims to find a safe way to treat high cholesterol without worsening blood sugar.
You likely qualify if…
You likely don't qualify if…
You will be randomly assigned to receive either or a placebo (a pill with no active ingredient) while continuing your cholesterol medication. Throughout the study, you'll have regular visits to provide blood samples so researchers can monitor your blood sugar, cholesterol, and insulin levels. The study will help determine whether adding the medication to your current treatment plan can safely prevent blood sugar problems.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
China