Plain-English translation of NCT07045727 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial studied whether getting in better physical shape before receiving CAR-T therapy could help older adults with multiple myeloma handle their cancer treatment better. CAR-T therapy is a powerful immunotherapy where doctors reprogram your own immune cells to attack cancer cells. The study tested whether a personalized exercise program done before treatment could improve how well patients recover and feel after their infusion.
CAR-T therapy can cause serious side effects including weakness, nerve damage, and loss of physical function — especially in older patients. This trial was designed to see if building up strength and fitness beforehand could help patients stay stronger and healthier during and after this demanding treatment.
Participants would receive a personalized exercise plan and use a health app to guide them through 6 weeks of aerobic and resistance training before their CAR-T infusion. They would also receive weekly coaching calls from a health coach for support and encouragement. Throughout the study, patients would have blood and urine samples collected to monitor their health.
AI-generated summary from trial data · Jul 12, 2026 · Not medical advice
United States