Testing melatonin to improve sleep and thinking in liver disease

This trial is testing whether melatonin, a natural hormone that helps regulate sleep, can improve both sleep quality and mental sharpness in people with cirrhosis (advanced liver disease). Cirrhosis often disrupts sleep and causes thinking problems that doctors currently struggle to treat well. The study will compare melatonin to thiamine (a B vitamin) to see which one works better for sleep and brain function.

People with cirrhosis frequently suffer from poor sleep and thinking difficulties, even when they're receiving standard treatments. Current medications used to treat these problems are expensive and hard to tolerate, so doctors need better, simpler options. This medication is being tested because it may help restore the body's natural sleep rhythms without the side effects of existing treatments.