Plain-English translation of NCT07051707 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our COPD research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing the dNerva Lung Denervation System, a new procedure designed to help people with moderate to severe COPD breathe better. The procedure uses a camera and special tools passed through the mouth into the lungs to calm overactive nerves that contribute to breathing problems. If it works, this treatment could be an important new option for people whose standard COPD medications alone aren't giving them enough relief.
Many people with COPD continue to struggle with breathing and quality of life even when they take their regular medications as prescribed. This trial exists to see whether this new minimally invasive procedure—which quiets the overactive nerves in the lungs that make breathing harder—could give these patients meaningful improvement beyond what their current medications provide.
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You will be randomly assigned to either receive the lung denervation procedure right away (in addition to continuing your regular COPD medications) or to continue your regular medications alone for one year. The procedure itself is a one-time, minimally invasive treatment performed through a bronchoscopy (a camera passed down your airway). You will have follow-up visits at regular intervals over one year to measure how well you are breathing, how you feel, and to check for any side effects. If you are in the medication-only group, you will have the option to receive the procedure after your one-year follow-up.
AI-generated summary from trial data · Jun 8, 2026 · Not medical advice
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