Testing a new cancer treatment before liver surgery for eye melanoma

Plain-English translation of NCT07057596 on ClinicalTrials.gov ↗ · Source last updated March 2026 · Translation generated July 2026 · How we translate trials

What is this trial?

This trial is testing a medication called to see if it can shrink or eliminate cancer in patients with eye melanoma that has spread to the liver before they have surgery. The medication works by helping your immune system recognize and attack cancer cells. Researchers believe giving this treatment before surgery might improve outcomes and help eliminate cancer completely.

Eye melanoma that has spread to the liver is very serious and difficult to treat. While this medication has shown promise in treating advanced eye melanoma, doctors want to know if using it before surgery—rather than after—can work better and help prevent the cancer from coming back.

Do you qualify?

You likely qualify if…

you have been diagnosed with melanoma that started in your eye and has spread to your liver
your cancer in the liver can potentially be removed with surgery, as determined by your doctor's team
you have a specific genetic marker (HLA-A*02:01) that makes you eligible for this treatment
you have not received any previous systemic cancer treatments like chemotherapy or immunotherapy for your advanced cancer
you are at least 18 years old and in good enough health to tolerate the medication and surgery
your blood counts and organ function (liver, kidneys) are adequate based on blood tests

You likely don't qualify if…

you have cancer that has spread outside your liver to other parts of your body
you have had a previous cancer (other than certain skin cancers) that was not cured at least 5 years ago
you have serious heart disease or an irregular heartbeat that requires treatment
you have had a severe allergic reaction to other biological medications or antibodies in the past
your liver function is significantly impaired based on blood tests

What participation looks like

You would receive weekly infusions of the medication for 6 months while doctors monitor your cancer with imaging every 2 months. After 6 months, you would have surgery to remove the cancer from your liver, scheduled for around month 7. After surgery, you would continue taking the medication for at least another year (possibly longer if your cancer has not returned completely) or until the cancer progresses or side effects become too difficult to manage.

Testing a new cancer treatment before liver surgery for eye melanoma

What is this trial?

Do you qualify?

What participation looks like

Trial locations(4 sites)