Plain-English translation of NCT07059741 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether combining four different types of treatment—radiation therapy, chemotherapy, autologous stem cell transplantation (ASCT), and CAR-T cell therapy—can help people with aggressive B-cell non-Hodgkin lymphoma whose cancer has come back or stopped responding to earlier treatments. The study divides patients into two groups based on how much cancer remains visible, giving each group a slightly different radiation dose to match their specific situation.
Aggressive B-cell lymphoma that returns or doesn't respond to standard treatments is very difficult to manage, and patients need new approaches. This trial combines several proven therapies in a specific sequence to see if working together they can achieve better results than any single treatment alone.
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You would receive a conditioning regimen combining radiation therapy and chemotherapy, followed by a stem cell transplant using your own cells, and then CAR-T cell therapy (a treatment that uses your own immune cells to fight cancer). After completing this combined treatment, you would attend regular follow-up visits to monitor how well the treatment works and watch for any side effects. The study will track your health and cancer status over time.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
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