Lidocaine infusion into brain blood vessels for severe chronic migraines

This trial is testing a procedure called bilateral middle meningeal artery lidocaine infusion for people with severe, long-lasting migraines that haven't responded to at least three different preventive medications. Lidocaine is a pain reliever already used safely in many medical procedures, but this is the first time doctors are studying it specifically for chronic migraines by infusing it directly into the blood vessels that supply pain signals to the brain. The research team has extensive experience performing similar procedures for other brain conditions and has already used this treatment successfully in a small group of early patients.

Despite advances in migraine medications, some patients continue to suffer from chronic, disabling migraines that don't improve with standard treatments. This trial exists to gather evidence about whether this new infusion approach can offer relief to people whose migraines have been resistant to conventional medications.