Comparing two bone-strengthening injections for osteoporosis in women

Plain-English translation of NCT07062978 on ClinicalTrials.gov ↗ · Source last updated July 2025 · Translation generated June 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This trial is testing whether , a new bone-strengthening injection, works as well as Prolia—an approved medication that helps prevent fractures in women after menopause. Both medications are given as injections under the skin. The study will compare how safe and effective each medication is in women with osteoporosis (weak bones) who are at higher risk of breaking a bone.

Osteoporosis causes bones to become weak and brittle, making fractures more likely—especially after menopause. Doctors need to know if this new medication can protect bones just as well as the current standard treatment, or perhaps even better.

Do you qualify?

You likely qualify if…

you are a postmenopausal woman between ages 50 and 85 who can walk freely
you have been diagnosed with osteoporosis with specific bone density measurements in a certain range
you have at least one fracture risk factor, such as a previous fragility fracture, family history of hip fracture, low body weight, age 65 or older, or current smoking
you have not had a menstrual period for at least 2 years, or you can confirm menopause through a blood test

You likely don't qualify if…

you have bone or metabolic diseases, overactive parathyroid glands, or thyroid disorders
you have kidney disease, rheumatoid arthritis, or conditions that affect nutrient absorption
you have had severe vitamin D deficiency or current dental disease, jaw infections, or recent jaw surgery
you have previously taken denosumab or certain other osteoporosis medications within the past year or 5 years
you have had more than two vertebral (spine) fractures or a history of cancer

What participation looks like

If you qualify, you will be randomly assigned to receive either or Prolia—both given as injections under the skin. You will attend multiple visits at the research center over the study period to receive your injections, have blood tests, and have bone density scans. The study team will monitor you closely to see how well the treatment works and to check for any side effects.

AI-generated summary from trial data · Jun 3, 2026 · Not medical advice

Trial locations(1 site)

China

Zhejiang Provincial People's Hospital Bijie Hospital, Guizhou