Plain-English translation of NCT07065630 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a new medication called combined with two standard chemotherapy drugs ( and ) for people with advanced head and neck cancer that is HPV-negative. The goal is to see how well this combination works before patients receive radiation therapy. After radiation, participants will continue taking the medication at a lower dose for nine months to help prevent cancer from returning.
Head and neck cancers that are HPV-negative tend to be harder to treat than HPV-positive cancers, and patients need better treatment options. This trial is exploring whether adding this new medication to standard chemotherapy can improve outcomes for patients with this harder-to-treat form of cancer.
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You would receive intravenous infusions of the three-drug combination (, , and ) in 21-day cycles for several months. After that initial treatment, you would receive radiation therapy to your cancer. Following radiation, you would continue taking the medication at a lower dose for nine additional months. You would need to attend regular clinic visits for blood tests, imaging scans, and check-ups throughout this entire period, which lasts approximately one year total.
AI-generated summary from trial data · Jul 6, 2026 · Not medical advice
United States
Phase
Testing effectiveness
Sponsor
University of Chicago
Enrollment target
~38 participants
Started
October 2025
Primary completion
August 2029
Age range
18 Years and older
Last updated on clinicaltrials.gov in March 2026.
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University of Chicago
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