Plain-English translation of NCT07065799 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our COPD research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study compares two ways to help your breathing if you have COPD (a serious lung disease) and your body is retaining too much carbon dioxide after a severe exacerbation. You'll try both treatments—a high-flow nasal cannula (a tube that delivers oxygen and air through your nose) and a home mechanical ventilator (a machine that helps you breathe)—each for three months, with a short break between them. The researchers want to know if the nasal device works just as well as the ventilator at reducing dangerous carbon dioxide levels in your blood.
Many people with COPD develop dangerously high carbon dioxide levels that don't go away quickly after a severe flare-up, and doctors aren't sure which breathing support method works best at home. This trial will help answer that question so patients can get the most effective treatment with the least disruption to their daily lives.
You likely qualify if…
You likely don't qualify if…
You'll visit the hospital or clinic multiple times over about six months (25 weeks total). You'll be randomly assigned to start with either the high-flow nasal breathing device or the home ventilator, using that treatment for three months while your doctors monitor how well it works. After a one-week break, you'll switch to the other breathing support method and use it for another three months. During both periods, researchers will measure your blood oxygen and carbon dioxide levels, and you'll be asked about how you're feeling and how the equipment is working for you.
AI-generated summary from trial data · Jun 26, 2026 · Not medical advice
Italy