Plain-English translation of NCT07073846 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether a combination of lidocaine and dexmedetomidine—two medications often used in surgery—can reduce pain and inflammation after bariatric (weight loss) surgery. The study compares the combination of both medications against each medication alone and a placebo to see which approach works best at controlling pain and speeding recovery.
Weight loss surgery triggers a strong inflammatory reaction in the body that can make pain worse and slow healing. Researchers believe this medication combination may block that inflammatory response and help patients recover faster and feel less pain after surgery.
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If you join this study, you will be randomly assigned to receive one of four treatments during your weight loss surgery: the two medications combined, lidocaine alone, dexmedetomidine alone, or a placebo saline infusion. The medication or saline will be given intravenously from the start of surgery until the surgeon closes your incision. Before and after surgery, the research team will collect blood samples to measure inflammation markers and monitor your heart rate and blood pressure closely. You will also be asked to rate your pain using standard questionnaires after surgery during your hospital stay.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
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