Combining immune therapy, radiation, and surgery for advanced liver cancer

Plain-English translation of NCT07075120 on ClinicalTrials.gov ↗ ·

What is this trial?

This study is testing whether combining —two medications that help your immune system fight cancer—along with focused radiation therapy and surgery can help people with advanced liver cancer that doctors initially thought could not be removed. The trial focuses especially on Native Hawaiian and Pacific Islander communities, who experience higher rates of this cancer and have been underrepresented in previous research.

Right now, many patients with borderline resectable liver cancer are told surgery isn't possible. The new treatment aims to shrink tumors enough to make surgery possible, and early research suggests combining these three approaches may work better than any single treatment alone.

Do you qualify?

You likely qualify if…

you have been diagnosed with liver cancer that is locally advanced or borderline resectable (meaning it may or may not be surgically removable)
you have not received any prior systemic treatment (chemotherapy or immunotherapy) for your liver cancer
you are at least 18 years old
your liver and kidney function are adequate, as shown by blood and urine tests
you do not have cancer that has spread outside your liver, to lymph nodes, or to other organs

You likely don't qualify if…

you have had radiation therapy to your liver before, or prior yttrium-90 treatment
you have active bleeding in your digestive tract or recent variceal bleeding (within 60 days)
you have hepatic encephalopathy (a brain condition caused by liver disease) within the past year
you have uncontrolled high blood pressure or are currently taking high-dose corticosteroids
you have active cancer elsewhere in your body (other than a prior cancer treated at least 5 years ago)

What participation looks like

If you enroll, you will first receive the immune medications () by infusion over nine weeks. After that, imaging scans will show whether your tumor has shrunk enough for surgery. If it has, you'll proceed directly to surgery. If not, you'll continue the immune medications and also receive focused radiation therapy (stereotactic body radiotherapy) in 3–5 sessions, with repeat imaging every nine weeks until surgery becomes possible. Throughout the trial, you'll have regular blood tests and imaging to monitor how your body responds.

Combining immune therapy, radiation, and surgery for advanced liver cancer

What is this trial?

Do you qualify?

What participation looks like

Trial locations(2 sites)