Recruiting

Testing stem cells to treat Crohn's disease inflammation

Plain-English translation of NCT07077746 on ClinicalTrials.gov ↗ · Source last updated June 2026 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing a new treatment called allogeneic HB-adMSCs (stem cells derived from fat tissue) to see if it can help people with Crohn's disease feel better and reduce their symptoms. Half of the participants will receive the stem cell infusions, and half will receive a placebo (salt water), so researchers can fairly compare how well the treatment works. The study will follow you for one year to measure improvements in your symptoms and blood work.

Crohn's disease causes painful inflammation in the digestive system, and current treatments don't work well enough for everyone. Researchers believe this medication may help calm the body's immune response and reduce that inflammation in a new way.

Do you qualify?

You likely qualify if…

you are between 18 and 65 years old
you have been diagnosed with Crohn's disease for at least 6 months before joining
your Crohn's disease is currently mild to moderate (based on symptom scores)
you have blood test results showing active inflammation (elevated CRP or ESR levels)
you are on a stable dose of Crohn's medications (or on no medications) and willing to keep them the same during the study
you have recent medical imaging or test results (within 3 years) that confirm your Crohn's disease diagnosis

You likely don't qualify if…

you are pregnant or planning to become pregnant during the study or for 6 months after treatment
you have changed your Crohn's disease medications in the last 3 months
you have severe Crohn's disease (very high symptom scores)
you cannot commit to keeping your current medications stable throughout the year-long study

What participation looks like

You will visit the research clinic multiple times over 52 weeks. At your first visit, you will receive an intravenous infusion of either the stem cell treatment or placebo. The research team will monitor you closely with blood tests, stool tests, and symptom questionnaires throughout the year to see how you're doing. You will need to continue taking your current Crohn's medications (if any) exactly as prescribed and report any side effects to the team.

AI-generated summary from trial data · Jun 23, 2026 · Not medical advice

Trial locations(1 site)

United States

Hope Biosciences Research Foundation, Sugar Land, Texas