Plain-English translation of NCT07082972 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether botulinum toxin (Botox) injections into the jaw muscles, a custom-fitted mouth guard worn at night, or a combination of both can help reduce pain and muscle tension in people with myofascial pain syndrome — a condition that causes chronic pain in the jaw and surrounding neck muscles. Researchers will measure how these treatments affect your muscle activity using a special test called electromyography (EMG), which records electrical signals from your muscles.
Many people suffer from jaw and neck pain that limits their ability to eat, speak, and enjoy life, but current treatment options are limited. This trial aims to find out whether this medication and/or a simple dental device can provide relief, either separately or when used together.
You likely qualify if…
You likely don't qualify if…
If you are selected, you will be randomly assigned to one of four groups: receiving botulinum toxin injections only, wearing a custom mouth guard only, receiving both treatments, or serving as a control group (no active treatment). You will have muscle activity measurements taken before your treatment, then again at 4 weeks and 12 weeks afterward. If you receive injections, a neurologist will administer them in a hospital setting; if you receive a mouth guard, impressions will be taken and a custom guard made for you to wear during sleep.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
Turkey (Türkiye)