Plain-English translation of NCT07085975 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
Researchers are testing a procedure where you inhale (ATP)—a natural substance found in your body—to trigger cough. This test, called an ATP cough challenge, helps doctors measure how sensitive your cough reflex is. The study wants to make sure this procedure is safe, works reliably, and can help identify patients who might benefit from new ATP-blocking treatments for chronic cough.
Chronic cough affects many people and can be hard to treat. Doctors need better tools to measure cough sensitivity and figure out which patients would benefit from new therapies. This study will help ensure the medication testing method is safe and reliable before it's used more widely.
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You will visit the research clinic and undergo an ATP cough challenge, where you inhale the substance through a device to trigger cough. Researchers will monitor your response and measure how sensitive your cough reflex is. The study also checks whether repeating this test gives consistent results. Healthy volunteers will complete the procedure once, while patients with chronic cough or asthma may participate in a second phase to test the procedure in those groups.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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