Plain-English translation of NCT07089251 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This study is testing whether epinephrine combined with tranexamic acid can reduce blood loss better than tranexamic acid alone during knee replacement surgery. Some patients will receive both medications during their operation, while others will receive only tranexamic acid. The goal is to see if the combination approach helps patients lose less blood and recover better.
Knee replacement surgery can cause significant bleeding, and managing that blood loss is important for patient safety and recovery. Researchers want to know if adding this medication to the standard treatment can reduce bleeding more effectively and improve outcomes for patients.
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If you join this study, you will be randomly assigned to receive either the medication combination or the single medication during your scheduled knee replacement surgery. The medications will be given intravenously (through an IV) as part of your normal surgical procedure. You will likely have follow-up visits to monitor your recovery and check how much blood you lost, but your main participation happens during and shortly after your surgery.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
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