Plain-English translation of NCT07094438 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Alzheimer Disease research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing two surgical approaches to treat severe Alzheimer's disease: one involves implanting electrodes in the brain to stimulate specific regions (called deep brain stimulation), and the other involves creating a surgical connection in the neck to improve fluid drainage from the brain (called lymphoid-venous anastomosis). Researchers will compare how well these two procedures work compared to medication alone, measuring whether they help improve memory, mood, and daily functioning.
Severe Alzheimer's disease causes significant decline in thinking and memory, and current medications have limited effectiveness. This trial exists to explore whether these two surgical approaches might offer new hope for people with advanced disease who haven't responded well to standard treatments.
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If enrolled, you will be assigned to one of three groups: brain stimulation surgery (with imaging to confirm proper electrode placement), neck surgery (with ultrasound and imaging to confirm the procedure), or medication treatment only. You will undergo examinations and tests to assess your thinking, mood, and quality of life at various points during the study. The exact duration and number of visits will depend on which group you're in, but you can expect regular follow-up appointments to monitor your progress and safety.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
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