Plain-English translation of NCT07099859 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
After you have surgery to replace a severely leaky aortic valve, your heart needs time to recover and remodel itself. This trial is testing whether losartan, a blood pressure medication, can help guide that healing process in the first three months after your operation. Researchers want to see if this medication—which has helped heart failure patients in other studies—might also benefit people recovering from aortic valve surgery.
Doctors often prescribe this type of medication after valve surgery based on what they've learned from heart failure research, but no one has actually studied whether it works for valve surgery patients. This trial aims to fill that gap and see if the medication truly helps the heart recover better.
You likely qualify if…
You likely don't qualify if…
You would take either the study medication or a placebo (a dummy pill with no active ingredient) once daily for three months after your valve surgery. During this time, you would have visits where doctors measure a heart protein in your blood and check how well your heart is healing. You would not know which pill you're taking—that's kept secret to make the results fair and unbiased.
AI-generated summary from trial data · Jul 1, 2026 · Not medical advice
Brazil
Phase
Post-approval monitoring
Sponsor
Vitor Emer Egypto Rosa
Collaborators
Fundação de Amparo à Pesquisa do Estado de São Paulo
Enrollment target
~60 participants
Started
July 2025
Primary completion
July 2029
Age range
18 Years – 85 Years
Last updated on clinicaltrials.gov in August 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Vitor E. E. Rosa, MD, PhD
Heart Institute of the School of Medicine of the University of São Paulo
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.