Recruiting

Testing a new medication combined with other cancer treatments for advanced stomach cancer

Plain-English translation of NCT07102901 on ClinicalTrials.gov ↗ · Source last updated September 2025 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing a new medication called SHR2554 in combination with other established cancer treatments for people with advanced stomach cancer that cannot be surgically removed. The study wants to learn whether this medication is safe to take, how well patients tolerate it, and whether it helps shrink or control the cancer. About 351 patients will participate across multiple hospitals.

Advanced stomach cancer is a serious disease where current treatment options have limited effectiveness. Researchers are testing this medication to see if combining it with existing treatments might offer patients better outcomes and longer survival.

Do you qualify?

You likely qualify if…

you are at least 18 years old
you have been diagnosed with advanced or metastatic stomach cancer or cancer of the gastroesophageal junction
you have at least one measurable tumor that can be seen on imaging scans
you are in good enough health to participate (ECOG performance status of 0 or 1)
you are willing to provide a tumor sample for testing
you are able to swallow pills without difficulty

You likely don't qualify if…

you have been treated before with a type of drug called an enhancer of zeste homolog inhibitor
you have serious, uncontrolled heart or blood vessel disease
you have active cancer in your spinal cord or brain that is causing symptoms or requiring treatment
you have an active autoimmune disease requiring ongoing steroid or immunosuppressant medications
you have a serious lung disease such as interstitial lung disease or a history of pneumonitis requiring steroids

What participation looks like

You would take the new medication by mouth as a tablet, combined with other standard cancer treatments that your doctor determines are appropriate for you. You would visit the hospital or clinic regularly for check-ups, blood tests, and imaging scans to monitor how the medication is working and watch for any side effects. The study involves multiple visits over time so doctors can carefully track your response to treatment and your safety.

AI-generated summary from trial data · Jun 4, 2026 · Not medical advice

Trial locations(2 sites)

China

Harbin Medical University Cancer Hospital, Harbin, Heilongjiang

The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan