New Immunotherapy Combined With Chemotherapy Before Surgery for Advanced Cervical Cancer

Plain-English translation of NCT07104149 on ClinicalTrials.gov ↗ · Source last updated August 2025 · Translation generated June 2026 · How we translate trials

Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.

What is this trial?

This trial is testing a new immunotherapy drug called cadonilimab combined with chemotherapy (a standard cancer drug called cisplatin) given before surgery in women with advanced cervical cancer. Researchers want to see if adding this medication to chemotherapy can shrink tumors more effectively and help surgeons remove the cancer completely. This is an early-stage trial with 29 participants.

Standard chemotherapy alone doesn't always shrink advanced cervical cancers enough to make surgery successful. This medication is designed to boost the body's immune system to fight cancer cells, and researchers believe combining it with chemotherapy might work better than either treatment alone.

Do you qualify?

You likely qualify if…

you are a woman 18 years or older
you have been diagnosed with cervical cancer at stage IB3, IIA2, IIB, or IIIC
your tumor can be removed surgically, according to your doctor
you have not received any previous chemotherapy, immunotherapy, or surgery for your current cancer
you are in good enough health to handle the treatment, with acceptable blood counts and organ function
you are willing to undergo surgery after the medication and chemotherapy treatment

You likely don't qualify if…

you have been treated with similar immunotherapy drugs before
you have been diagnosed with another type of cancer in the past 5 years
you have an active autoimmune disease that requires ongoing treatment
you have a known allergy to cisplatin or the study medication
you have an active, untreated infection such as HIV or hepatitis B

What participation looks like

Over about 9–12 weeks, you would receive the medication and chemotherapy together through an IV every three weeks, for a total of 2–4 treatment cycles. After treatment, imaging scans would check how well the tumor has shrunk. Then you would have surgery to remove the cancer. Your doctors would monitor you closely for side effects throughout the trial and may recommend additional treatment after surgery if needed.

AI-generated summary from trial data · Jun 4, 2026 · Not medical advice

Trial locations(1 site)

China

The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan