Testing a psychedelic medication combined with talk therapy for trauma

This research study is testing psilocybin, a psychedelic compound, as a treatment for people with post-traumatic stress disorder (PTSD) and depression. The study compares two approaches: receiving the medication with standard supportive counseling, or receiving it with counseling plus an active mindfulness-based therapy. Researchers will use brain imaging and brain activity recordings to understand how this medication works and whether adding mindfulness training makes a difference.

Many people with PTSD don't get better with the medications and talk therapies that are currently approved, so researchers are exploring whether this medication might help when standard treatments haven't worked. This trial is also trying to understand exactly how the medication affects the brain and which type of counseling support works best alongside it.