Recruiting

Testing two medications together for liver disease bleeding risk

Plain-English translation of NCT07108075 on ClinicalTrials.gov ↗ · Source last updated August 2025 · Translation generated July 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing whether combining with — a blood pressure medication — works better than alone at reducing the dangerous pressure that builds up in livers damaged by cirrhosis. The study will measure pressure inside your liver to see if the combination treatment provides better protection against future bleeding complications.

People with advanced liver disease face serious risks from bleeding and other complications caused by high pressure in the liver. While is already used to help prevent these problems, researchers want to see if adding this medication might provide even better protection by working through a different mechanism in the body.

Do you qualify?

You likely qualify if…

you have been diagnosed with liver cirrhosis and have experienced variceal bleeding (bleeding from enlarged veins in the food pipe)
you are between 18 and 75 years old
you have not taken metformin, beta-blockers, or carvedilol in the past 5 days
you have a heart rate and blood pressure stable enough to safely take the study medications

You likely don't qualify if…

you have severe liver disease (CTP Score of 12 or higher)
you are currently taking metformin, beta-blockers, or carvedilol
you have very high bilirubin levels (over 3 mg/dL) or kidney problems
you have asthma, heart failure, or a heart rate lower than 60 beats per minute
you have advanced liver disease complications like hepatic encephalopathy (confusion from liver failure) or cancer

What participation looks like

You will receive one of two treatment options: either the combination of both medications or alone. Researchers will measure the pressure inside your liver using a special test to see how well your assigned treatment reduces it. The study is double-blinded, meaning neither you nor the doctors will know which treatment you're receiving until the study ends, helping ensure fair and unbiased results.

Testing two medications together for liver disease bleeding risk

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)