Plain-English translation of NCT07116772 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Hydroxyurea is a medicine that helps many people with sickle cell anemia by reducing pain, strokes, and other serious complications. However, doctors still don't know enough about how this medication affects teenagers and young adults as they grow up, go through puberty, and think about having children—especially in countries with fewer medical resources. This study will follow people with sickle cell anemia over time to answer these important questions.
While this medication is known to help with sickle cell disease, there are gaps in understanding its long-term effects on development, fertility, and pregnancy. Researchers want to fill these knowledge gaps, particularly for young people in areas where medical care is harder to access.
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You will visit the clinic every few months for health check-ups and blood tests. Girls who have started their periods will take pregnancy tests every six months, and boys may be asked to provide a semen sample if they agree. You will also answer regular questions about your health and fertility to help researchers understand how the medication affects your development and reproductive health over time.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
Dominican Republic
Jamaica
Tanzania
Sponsor
Children's Hospital Medical Center, Cincinnati
Collaborators
The University of The West Indies, Centro de Obstetricia y Ginecologia Recruiting Santo Domingo, Dominican Republic
Enrollment target
~250 participants
Started
July 2023
Primary completion
May 2035
Age range
8 Years and older
Last updated on clinicaltrials.gov in February 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Teresa Latham, DrPh
Children's Hospital Medical Center, Cincinnati
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.