Plain-English translation of NCT07118345 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether performing decompressive hemicraniectomy—a surgical procedure that removes part of the skull to relieve pressure—early after endovascular thrombectomy (a procedure to remove blood clots from brain arteries) can improve outcomes in patients with very large strokes. The study compares patients who receive this preventive surgery right away with those who receive standard medical care and only have surgery later if complications develop.
About half of patients with very large strokes develop dangerous brain swelling after clot removal, which dramatically worsens their chances of recovery and survival. While this emergency surgery has been shown to save lives when done early, it's often delayed until swelling becomes life-threatening, by which time it may be too late to help.
You likely qualify if…
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If you join this trial, you will receive endovascular thrombectomy (clot removal) as standard care. After that procedure, you will be randomly assigned to either have emergency brain surgery right away to prevent swelling, or to receive standard medical care with the option of surgery later if swelling develops. You will stay in the hospital for monitoring and follow-up visits at 90 days and beyond to check your recovery and brain function.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
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