Comparing two knee injection treatments for arthritis pain

This study is testing whether combining microfragmented autologous adipose tissue with hyaluronic acid works better than microfragmented autologous adipose tissue alone for treating knee osteoarthritis. Both treatments use fat tissue harvested from your own abdomen, which is then broken down into tiny pieces and injected directly into your knee. The trial will compare these two approaches to see which one reduces pain and improves function better over two years.

Osteoarthritis causes the protective cartilage in your knees to wear down, leading to pain and stiffness that doesn't improve with standard treatments like medication or physical therapy. This trial is exploring whether using your own fat tissue—combined with a natural substance that lubricates joints—might be a better way to relieve that pain and restore knee function.