Plain-English translation of NCT07121894 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a ketogenic diet (a high-fat, low-carbohydrate eating plan) can help improve depression in people with bipolar disorder. Researchers at Mayo Clinic want to understand how this special diet affects mood and overall health in people who have been diagnosed with bipolar I, bipolar II, or bipolar schizoaffective disorder. The study will follow 30 participants to see whether the diet helps reduce depressive symptoms and improve physical health markers.
Current treatments for bipolar depression don't work equally well for everyone, and doctors are looking for additional options to help patients who don't respond adequately to medication alone. Early research suggests that the ketogenic diet may help stabilize mood and improve depression, but more careful study is needed to confirm whether this treatment is safe and effective for people with bipolar disorder.
You likely qualify if…
You likely don't qualify if…
You would be asked to change your diet to a high-fat, low-carbohydrate ketogenic plan while continuing your current bipolar medications. The study will monitor your mood symptoms, physical health (including blood sugar and cholesterol levels), and how well you tolerate the diet. You'll likely have regular check-ins with the study team, possibly through visits and smartphone-based monitoring, though the exact schedule isn't specified in this summary.
AI-generated summary from trial data · Aug 28, 2026 · Not medical advice
United States
Sponsor
Mayo Clinic
Enrollment target
~30 participants
Started
August 2025
Primary completion
December 2028
Age range
18 Years – 50 Years
Last updated on clinicaltrials.gov in August 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Karin Lindstrom, PhD
Mayo Clinic
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.