Plain-English translation of NCT07121894 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing whether a ketogenic diet—a high-fat, low-carbohydrate eating plan—may help reduce depression symptoms in people with bipolar disorder. Researchers want to understand how this diet affects mood and overall physical health in people who already take mood-stabilizing medications. The study aims to see if this treatment approach could be a helpful addition to standard bipolar care.
Current treatments for bipolar depression don't work for everyone, and doctors are looking for additional options that might help. Early research suggests that this dietary approach may influence brain chemistry and mood, but it needs careful testing in people with bipolar disorder to see if it's safe and effective.
You likely qualify if…
You likely don't qualify if…
If you join this study, you will commit to following a high-fat, low-carbohydrate diet while continuing your current mood-stabilizing medications. You will have regular visits with the study team to monitor your mood symptoms, overall health, and any changes in your physical well-being. The study will track how you respond to the diet and check your heart health and metabolic markers through blood tests and questionnaires.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States
Sponsor
Mayo Clinic
Enrollment target
~30 participants
Started
August 2025
Primary completion
December 2028
Age range
18 Years – 50 Years
Last updated on clinicaltrials.gov in January 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Karin Lindstrom, PhD
Mayo Clinic
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.