Receive radiation therapy followed by immune-boosting medications for liver cancer

Receive radiation therapy followed by immune-boosting medications for liver cancer | stella

What is this trial?

This trial is testing a combination approach for people with advanced liver cancer that has spread to blood vessels in the liver. You would first receive a specialized radiation treatment called SIRT (selective internal radiation therapy), which delivers radiation directly to the cancer using tiny glass beads. About 1–3 weeks later, you would start taking two immune-boosting medications: and (also called Imjudo and Imfinzi). These medications help your body's immune system recognize and fight the cancer.

Liver cancer with blood vessel involvement is very hard to treat with surgery or other standard approaches, and patients with this type of cancer have limited treatment options. This trial is testing whether combining targeted radiation with immune-boosting therapy can control the cancer better than either treatment alone.

Do you qualify?

You likely qualify if…

you are 18 years old or older
you have been diagnosed with liver cancer that involves the portal vein (a major blood vessel in the liver)
your cancer cannot be treated with surgery, ablation, or transplantation
your cancer affects less than 50% of your liver
you have adequate liver, kidney, and blood cell function based on lab tests
you have not had any previous immune-boosting medications for cancer

You likely don't qualify if…

you have cancer that has spread outside the liver (except for small lymph nodes)
you have signs of liver failure such as fluid buildup in the abdomen or brain swelling related to liver disease
you have lung disease or low oxygen levels in your blood
you have had previous liver radiation therapy or multiple prior embolization treatments
you have a history of organ transplant or serious immune system problems

What participation looks like

You would first undergo the radiation procedure, which involves inserting a catheter into an artery to deliver radioactive glass beads directly to your liver cancer. After 1–3 weeks, you would begin receiving the immune-boosting medications as intravenous (IV) infusions, starting with one dose of followed by doses of every 4 weeks. You would continue treatment and be monitored for up to 18 months, with regular imaging scans and blood tests to check how you are responding and watch for any side effects.

AI-generated summary from trial data · Jun 16, 2026 · Not medical advice

Radiation and immune-boosting drugs for advanced liver cancer

What is this trial?

Do you qualify?

What participation looks like

Trial locations(6 sites)