Try a daily supplement alongside your antipsychotic medication for psychosis

Recruiting

What is this trial?

This trial is testing medium-chain triglyceride oil (MCT oil)—a supplement that may help your brain use energy more efficiently—as an add-on to your current antipsychotic medication. The study involves taking MCT oil twice daily for 12 weeks while continuing your regular psychiatric treatment. Researchers want to see if this supplement can improve how your brain uses glucose and ketones for energy, and whether it helps reduce psychosis symptoms.

Many people with psychosis have underlying problems with how their brain uses energy for fuel—something that happens even before starting antipsychotic medications. While antipsychotics are the main treatment, they don't work completely for everyone, and they can sometimes cause metabolic side effects like weight gain and blood sugar problems. This medication offers a potential way to support brain energy metabolism without major diet changes, something that might help both symptoms and overall health.

Do you qualify?

You likely qualify if…

you are a young adult recently referred to a psychosis clinic (either as an outpatient or inpatient)
you have been diagnosed with first-episode psychosis and are currently taking a stable dose of antipsychotic medication for at least 4 weeks
you are able to read, understand, and communicate in English or French
you are able to understand the study and provide your informed consent to participate

You likely don't qualify if…

you are pregnant, have given birth in the past 6 months, or are breastfeeding
you have been diagnosed with type 1 or type 2 diabetes
you have used MCT oil, ketone supplements, or followed a ketogenic diet in the past year
you have a history of pancreatitis or liver failure, or genetic metabolic conditions affecting fat metabolism
you are currently experiencing severe or uncontrolled suicidal thoughts

What participation looks like

You would continue taking your regular antipsychotic medication and add MCT oil to your daily routine—15 grams mixed into a drink of your choice, twice a day (morning and evening), for 12 weeks. The study will monitor your blood work to measure ketone levels, blood sugar, and insulin, along with checking how you're feeling and whether the supplement is easy to use. You'll need to attend clinic visits for check-ins and blood tests during the 12-week period.

Adding a Metabolic Supplement to Antipsychotic Treatment for First Episode Psychosis

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)