Plain-English translation of NCT07124351 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether pafolacianine (CYTALUX™), a special fluorescent dye, can help surgeons better detect and remove cancerous tumors in your stomach, esophagus, or appendix during surgery. The dye is given by injection before your operation and glows under special near-infrared light, allowing surgeons to see cancer cells more clearly. This is an early-stage study with 15 participants to see if this approach is safe and works well.
During cancer surgery, it can be difficult for surgeons to see all the cancer cells, especially very small ones or cancer that has spread. This medication could help surgeons identify and remove more cancer during the operation, potentially improving outcomes and reducing the need for additional surgeries.
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You will receive an injection of the fluorescent dye through an IV (intravenous line) sometime between 1 hour and 24 hours before your scheduled surgery. The dye infusion takes about an hour to complete. During your surgery, surgeons will use special near-infrared imaging equipment to see where the dye has lit up cancer cells, helping them identify and remove more of the tumor. After your surgery, you will be followed according to standard post-operative care.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
United States
Phase
Post-approval monitoring
Sponsor
Cedars-Sinai Medical Center
Collaborators
On Target Laboratories, LLC
Enrollment target
~15 participants
Started
September 2025
Primary completion
August 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in September 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Amy Hoang
Cedars-Sinai Medical Center
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.