Mind-Body Program for Nerve Pain in the Lower Back and Leg

Plain-English translation of NCT07125027 on ClinicalTrials.gov ↗ · Source last updated November 2025 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing Move-MORE, a new program that combines mindfulness training, guided physical activity, and motivational coaching to help people with lumbosacral radiculopathy—a condition where nerve pain radiates from the lower back down into the leg, often called sciatica. The program is designed as a non-surgical, medication-free alternative for people whose pain hasn't improved with conventional treatments.

Sciatica and lower back nerve pain affect millions of people and can become long-lasting and difficult to treat with surgery or medication alone. This trial exists to develop and test a new approach that uses mindfulness and movement to help people manage their pain and improve their quality of life.

Do you qualify?

You likely qualify if…

you are between 18 and 65 years old
you have had nerve pain radiating from your lower back into your leg (below the knee) for at least 12 weeks
you can stand for at least 10 minutes
you have a physical exam finding that confirms lumbosacral radiculopathy (such as a positive straight leg raise test or nerve-related weakness or numbness)
you have reliable internet access and are willing to participate 4–5 times per week on your own plus attend a weekly 2-hour online session for 8 weeks
you are moderately motivated to participate (rating at least 4 out of 10 on motivation)

You likely don't qualify if…

you have rapidly worsening nerve damage or weakness in your lower legs
you have signs of cauda equina syndrome, a serious spinal condition requiring emergency care (such as new loss of bladder or bowel control, numbness in your buttocks or inner thighs, or severe weakness in both legs)
you have severe or moderate foot drop (difficulty lifting your foot when walking)
you have intolerable pain that cannot be managed during the study

What participation looks like

Over 8 weeks, you would join a weekly 2-hour online group session via Zoom and practice the mindfulness and exercise program on your own 4–5 times per week. You'll attend two in-person visits and one follow-up visit, complete surveys about your pain and well-being, wear a small activity tracker throughout the study, and answer brief daily check-ins about your pain via your phone or computer. The study collects information at the start, middle, end, and 3 months after the program finishes to see how much the treatment helps.

AI-generated summary from trial data · Jun 13, 2026 · Not medical advice

Mind-Body Program for Nerve Pain in the Lower Back and Leg

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)