Plain-English translation of NCT07126158 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial combines radiation therapy (a focused beam treatment) with two medications called and to treat advanced pancreatic cancer. The study will enroll 36 people and test whether this combination helps patients live longer without their cancer progressing compared to radiation alone. You would take the medications by mouth for about 12 months while receiving radiation over five sessions.
Pancreatic cancer is very aggressive, and people with advanced disease that cannot be surgically removed have limited treatment options. Researchers believe that combining targeted medications with radiation might work better than radiation alone to slow cancer growth and improve survival.
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You would receive five sessions of focused radiation therapy to your pancreas over a few weeks while starting the two oral medications on the second day of radiation. You would take one medication twice daily and the other twice weekly on a schedule of 3 weeks on, 1 week off, for about 12 months total. If your cancer becomes resectable during treatment, you would have surgery and pause the medications for recovery, then resume them afterward. You would have regular clinic visits and blood tests to monitor how well the treatment is working and check for side effects.
AI-generated summary from trial data · Jun 24, 2026 · Not medical advice
United States