Plain-English translation of NCT07132190 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a new approach to radiation therapy for brain metastases (cancer that has spread to the brain). Instead of planning your treatment days or weeks in advance, doctors will take a fresh MRI scan on the day you receive radiation and adjust your treatment plan in real time. This adaptive approach may help reduce the area around your tumor that receives radiation, potentially lowering the risk of side effects while keeping the cancer under control.
Standard radiation planning happens before treatment, so doctors add extra margins (buffer zones) around tumors to account for any shifts in your position or anatomy that might occur during the weeks between planning and treatment. This trial tests whether same-day planning and tighter margins can improve outcomes by reducing unnecessary radiation to healthy brain tissue while still effectively treating the cancer.
You likely qualify if…
You likely don't qualify if…
You will first have a standard radiation plan created from an initial MRI scan. Then, on the day of your radiation treatment, you will have a second MRI scan in the hospital, and your treatment plan will be adjusted based on your anatomy that day. Your radiation therapy will be delivered the same day after this updated plan is finalized. You will be randomly assigned to receive either very tight safety margins (0mm) or slightly larger standard margins (1mm) around your tumor.
AI-generated summary from trial data · Jun 28, 2026 · Not medical advice
United States