Plain-English translation of NCT07132307 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a mandibular advancement device — a custom-fitted dental appliance that gently moves your lower jaw forward while you sleep — for people with obstructive sleep apnea whose previous treatment with hypoglossal nerve stimulation didn't work. The device is designed to keep your airway open during sleep, reducing the breathing interruptions that characterize sleep apnea. Researchers want to see if this approach can help when other treatments have failed.
Some people with sleep apnea don't tolerate or benefit from hypoglossal nerve stimulation therapy, leaving them without effective treatment options. This trial explores whether a dental device could be a better alternative for these patients.
You likely qualify if…
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You would receive a custom-fitted dental device designed to advance your lower jaw forward while you sleep. Throughout the study, you would wear the device nightly and complete home sleep tests to measure how well it's working. You'll also attend assessments at Washington University and participate in remote check-ins using your internet-connected device. During the entire study, you would not use any other treatments for sleep apnea.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
United States
Sponsor
Washington University School of Medicine
Enrollment target
~30 participants
Started
July 2025
Primary completion
February 2027
Age range
18 Years – 70 Years
Last updated on clinicaltrials.gov in March 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Jay F Piccirillo, MD
Washington University School of Medicine
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.