Plain-English translation of NCT07134153 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Breast Cancer research guide →Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing a medication called that is injected directly into the cerebrospinal fluid (the fluid surrounding your brain and spinal cord) to treat breast cancer that has spread to the brain or its protective lining. The study will first figure out the safest and most effective dose, and then test how well this approach works for patients whose brain tumors are not responding to standard treatments. Researchers hope this direct delivery method will get the medication where it needs to go more effectively than regular intravenous infusions.
Currently, patients with breast cancer that has spread to the brain have very limited treatment options and survival times are short—often only 3 to 4 months. Most cancer medications don't reach the brain well because of a natural barrier that protects the brain, so doctors need new ways to deliver treatment directly to where the cancer is growing.
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Depending on which group you are assigned to, you may receive the medication in different ways: either starting with a spinal injection alone, then combining it with intravenous infusions, or starting with an IV infusion and then switching to spinal injections. The first phase of the study focuses on finding the right dose, while the second phase tests how well the treatment works. You will have regular visits for imaging scans, blood tests, and checkups to monitor how you are responding and for any side effects.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
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