Plain-English translation of NCT07139899 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers want to understand how mucus buildup in airways affects the rest of your lungs in people with severe asthma. This study uses two types of imaging — a CT scan to find mucus plugs and a special xenon MRI scan to measure how well your lungs are working — in patients starting new biologic medications like dupilumab, tezepelumab, or benralizumab. The goal is to learn how these medications help improve lung function by reducing mucus.
In severe asthma, mucus can plug up airways and damage how the lungs work downstream of those blockages. Researchers don't fully understand exactly how this happens or how well new biologic treatments reverse this damage, so this study aims to fill that gap using advanced imaging.
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You would have imaging scans done — first a CT scan to identify mucus plugs in your airways, then a xenon MRI scan to measure how well air moves through your lungs and how well your lungs exchange oxygen. These scans would happen as you start your new biologic medication as part of your regular asthma care. The study involves a small number of participants (about 5 people) and appears to focus on understanding what happens in your lungs after you begin the treatment.
AI-generated summary from trial data · Jul 2, 2026 · Not medical advice
United States
Sponsor
Bastiaan Driehuys
Collaborators
University of Kansas Medical Center, Polarean, Inc.
Enrollment target
~5 participants
Started
November 2025
Primary completion
November 2026
Age range
18 Years – 65 Years
Last updated on clinicaltrials.gov in November 2025.
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Central contact
David Mummy, PhD
Duke University
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