Plain-English translation of NCT07142213 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study is looking at how the liver regenerates (grows back) after a special two-stage surgical procedure called ALPPS, which is used to treat advanced liver cancer. During this procedure, doctors first partially separate the liver and tie off a major blood vessel to encourage rapid growth of the remaining liver tissue. Then, in a second surgery weeks later, they remove the cancer. Researchers will study tissue samples and medical data collected during your standard surgical care to understand what happens at the cellular and genetic level when your liver regrows.
Many patients with liver cancer have tumors that are too large or spread too widely to remove safely in one operation, because removing them would leave too little healthy liver behind to support life. This two-stage procedure helps the liver grow larger between surgeries, making it safer to remove the cancer completely. However, doctors don't fully understand how well this regenerated liver works long-term or whether it affects cancer recurrence, and this study aims to answer those questions.
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If you qualify and choose to participate, your involvement centers on your standard surgical care—no extra procedures are being added to the study. During your two-stage ALPPS surgery, doctors will collect small samples of liver tissue during your operations and gather your medical information as part of routine care. Researchers will then analyze these samples using advanced laboratory techniques to understand how your liver cells change and communicate during the healing process. You'll be followed according to your normal cancer follow-up schedule, and the study team will track your recovery and long-term outcomes.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
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