MRI-guided radiation therapy for prostate cancer that returned after prior radiation

Plain-English translation of NCT07142967 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated July 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing whether MR-Linac-guided stereotactic body radiotherapy (a precise, advanced form of radiation delivered with real-time MRI guidance) is safe and effective for treating prostate cancer that has come back after previous radiation therapy. The study will also track side effects, especially urinary problems, to make sure the new treatment is safe for patients who've already received radiation.

When prostate cancer returns in the same spot after radiation therapy, doctors have limited treatment options. This trial exists to see whether this new MRI-guided radiation approach can safely treat recurrent cancer without causing serious harm to the bladder and surrounding tissues.

Do you qualify?

You likely qualify if…

you are at least 18 years old and male
you have been diagnosed with prostate cancer that has returned inside the prostate after prior radiation therapy, confirmed by a biopsy
you have adequate testosterone levels (above 50 ng/dL)
you are in good overall health, able to care for yourself with minimal help (Karnofsky score of 80% or higher)
you are willing to come for follow-up visits for at least 2 years and can be reached by phone or medical records review after that
you have a visible lesion on an MRI scan of your prostate

You likely don't qualify if…

you have received brachytherapy (radioactive seed implants) for your prostate in the past
you are currently taking hormone therapy for prostate cancer at the time of enrollment
you have imaging evidence that the cancer has spread outside the prostate or to lymph nodes
you have an MRI-unsafe implant like a pacemaker or metallic device in your pelvis
you have inflammatory bowel disease (Crohn's disease or ulcerative colitis)

What participation looks like

You would receive specialized radiation therapy using an MRI-Linac machine, which combines MRI imaging with radiation delivery to precisely target the cancer in your prostate. The radiation treatment would be planned and adjusted in real-time using MRI images to spare healthy tissue. You would also receive 4 to 6 months of hormone therapy (androgen deprivation therapy) alongside the radiation. You would need to attend treatment sessions and return for follow-up appointments over 2 years, including imaging scans, blood tests, a prostate biopsy, and surveys about urinary symptoms.

AI-generated summary from trial data · Jul 21, 2026 · Not medical advice

Trial locations(1 site)

United States

NYU Langone Health, New York, New York