Plain-English translation of NCT07143734 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This is a pilot study testing transcranial pulse stimulation (TPS), a device that delivers gentle sound wave pulses to the brain to see if it can help improve memory, thinking, and mood in people with early-stage Alzheimer's disease. Half of the participants will receive the active treatment, while the other half will receive a sham treatment (a device that feels and sounds the same but doesn't deliver the therapeutic pulses). Researchers will measure changes in cognitive function and brain activity over 12 weeks.
Alzheimer's disease causes progressive memory loss and cognitive decline, and current treatment options are limited. This trial is exploring whether this non-invasive sound wave technology might offer a new way to support brain function and slow cognitive decline in people with early-stage disease.
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You would visit the research center for treatment sessions over 12 weeks, with intensive sessions during the first two weeks and then additional sessions at regular intervals. During each session, you would receive either the active sound wave stimulation or sham treatment (you won't know which). You'll also have brain imaging scans, memory and thinking tests, and blood tests at the start and end of the study to help researchers measure any changes.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
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