Plain-English translation of NCT07144826 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing whether a specific probiotic supplement — a mix of five beneficial bacteria strains — can help protect your gut health during chemotherapy for ovarian cancer. Chemotherapy can disrupt the healthy bacteria in your digestive system, which may contribute to side effects like nausea, constipation, or diarrhea. Researchers want to see if taking this medication twice daily during your chemotherapy cycles can maintain a healthier gut microbiome and reduce treatment-related complications.
Chemotherapy drugs used to treat ovarian cancer can kill both cancer cells and beneficial bacteria in your gut, leading to digestive problems and potentially affecting how well your body tolerates treatment. This study exists to find out whether this medication can preserve your natural gut bacteria and improve your quality of life during cancer treatment.
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You would take a probiotic supplement by mouth twice each day, starting within one week of beginning your first chemotherapy cycle and continuing through one week after your sixth chemotherapy cycle (about 6 months total). Throughout the study, you will provide blood samples and vaginal swab samples at various points to help researchers track changes in your gut and vaginal bacteria. You'll also answer questions about your diet and how you're feeling. About half of participants will receive the actual probiotic, while the other half will receive a placebo (an inactive pill that looks identical), though neither you nor your doctors will know which one you're taking.
AI-generated summary from trial data · Jul 18, 2026 · Not medical advice
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