Plain-English translation of NCT07153276 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This study is testing two different approaches to treat vaginal dryness in people with Sjögren's disease, an autoimmune condition that affects moisture-producing glands. Half the participants will receive fractional CO2 laser treatments applied to the vagina, while the other half will use a topical medication called promestriene. The trial will last 6 months and involve 60 women to see which approach works better.
Vaginal dryness is a common and uncomfortable symptom of Sjögren's disease that can significantly affect quality of life. Researchers want to compare a newer laser-based approach with a traditional medication to help doctors and patients choose the most effective treatment option.
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You will be randomly assigned to receive either monthly vaginal laser treatments (three sessions over three months) or nightly vaginal medication capsules for two weeks, followed by applications three times per week for the remainder of the 6-month study. You will attend clinic visits to receive treatments or pick up medication and to have your symptoms monitored throughout the study period.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
Brazil