Plain-English translation of NCT07159061 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a new approach called real-time fMRI neurofeedback to treat major depression. During the study, you'll receive brain imaging feedback designed to help you retrain how your brain responds to negative thoughts and emotions. Researchers want to see if this brain-based training can reduce depression symptoms and help people feel better.
Current depression treatments don't work equally well for everyone, and some people don't benefit from medication or therapy alone. This trial explores whether giving people real-time feedback about their own brain activity could help them learn to change unhelpful thought patterns and reduce depression in a new way.
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You will attend three training sessions, each lasting about 32 minutes, where you'll lie in an MRI brain scanner and receive real-time feedback about your brain activity as you view images and perform simple tasks. Half of participants will receive actual brain feedback (active group), while the other half will receive neutral feedback that doesn't respond to their brain (control group). Throughout the study, you'll also complete questionnaires and tests to measure changes in your depression symptoms and mood.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
United States