How well do newer migraine medications work in real-world use

This is a two-year study that tracks how well newer migraine medications—including erenumab, galcanezumab, fremanezumab, eptinezumab, atogepant, and rimegepant—work in real-world settings. Researchers will follow about 700 people with migraine who are starting one of these treatments to see how effective the medication is, what side effects people experience, and how it affects quality of life. You'll visit the clinic every 6 months so doctors can check how you're doing.

These newer migraine medications target a specific pathway in the brain and have shown promise in clinical trials, but researchers want to understand how well they actually work for people in everyday life—not just in controlled research settings. This study helps doctors learn which patients benefit most and how to use this treatment most effectively.