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Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a new combination approach to treating large brain tumors and cancer that has spread to the brain. Instead of using just one radiation machine, researchers are combining two specialized machines—a linear accelerator and a Gamma Knife—to deliver radiation therapy. The goal is to improve how well the treatment works while reducing side effects like swelling and damage to healthy brain tissue.
When brain tumors are large, standard radiation therapy alone can sometimes be less effective and carry a higher risk of harming healthy brain tissue. This trial exists to see if combining two different radiation machines with a break between treatments might achieve better tumor control and fewer complications, by allowing doctors to rescan and adjust targeting partway through treatment.
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You would receive 4 days of radiation treatment using a linear accelerator machine. After a 1–2 week break (during which you'll have new scans so doctors can see if the tumor has shrunk and adjust targeting), you'll receive one final radiation treatment using the Gamma Knife machine. Throughout the study, you'll have follow-up appointments with imaging scans to monitor how well the treatment is working and watch for any side effects. The entire treatment course takes about 2–3 weeks from start to finish.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
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